Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Methylenetetrahydrofolate Dehydrogenase (NADP) Terms and Definitions

Methylenetetrahydrofolate Dehydrogenase (NADP)

Medical Definition:	An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYTHASE.
Guide Notes:	do not confuse with METHYLENETRAHYDROFOLATE DEHYDROGENASE (NAD+)
CAS Type 1 Name:	CAS Number:	EC 1.5.1.5
Previously Indexed:	Oxidoreductases (1973-1974),Tetrahydrofolates (1973-1974)

CANADIAN MEDICAL GUIDE

Thank you for visiting Canadian Medical Guide .com