Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Methylenetetrahydrofolate Dehydrogenase (NADP) Terms and Definitions
Methylenetetrahydrofolate Dehydrogenase (NADP)
| Medical Definition: | An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYTHASE. | |
| Guide Notes: | do not confuse with METHYLENETRAHYDROFOLATE DEHYDROGENASE (NAD+) | |
| CAS Type 1 Name: | CAS Number: | EC 1.5.1.5 |
| Previously Indexed: | Oxidoreductases (1973-1974),Tetrahydrofolates (1973-1974) |
Methylenetetrahydrofolate Dehydrogenase (NADP) Medical Definitions and Terms
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