Canadian Medical Guide > Chemicals and Drugs > Organic Chemicals > Organophosphorus Compounds Terms and Definitions

Organophosphorus Compounds

Medical Definition:	Organic compounds that contain phosphorus as an integral part of the molecule.
Guide Notes:	includes organopyrophosphorus cpds; organophosphates & organopyrophosphates go under Phosphoric Acid Esters; /antag permitted but consider also CHOLINESTERASE REACTIVATORS; DF: ORGANOPHOSPHORUS CPDS
Previously Indexed:	Phosphates (1966-1970),Phosphonic Acids (1966-1970),Phosphoric Acids (1968-1970),Phosphorous Acids (1968-1970),Phosphorus (1966-1970)

Organophosphorus Compounds Categories.

	Aminoethylphosphonic Acid - An organophosphorus compound isolated from human and animal tissues.
	Armin - A reversible organophosphorus cholinesterase inhibitor. It also affects the presynaptic membrane and inhibits membrane postsynaptic cholinergic receptors. The compound had former use as a miotic.
	Chlorfenvinphos - An organophosphorus cholinesterase inhibitor that is used as an insecticide and an acaricide.
	Dichlorvos - An organophosphorus insecticide that inhibits acetylcholinesterase.
	Diphosphonates - Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
	Fosinopril - A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.
	Hempa - A chemosterilant agent that is anticipated to be a carcinogen.
	Isoflurophate - An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)
	Mevinphos - An organophosphate cholinesterase inhibitor that is used as an insecticide.
	Monocrotophos - An organophosphate insecticide that inhibits monoamine oxidase and acetylcholinesterase. It has been shown to be genotoxic.
	Naled - An organophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.
	Paraoxon - An organophosphate cholinesterase inhibitor that is used as a pesticide.
	Phosphamidon - An organophosphate cholinesterase inhibitor that is used as an insecticide.
	Phosphoric Acid Esters - Organic esters of phosphoric acid.
	Sarin - An organophosphorous ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervous system and is a chemical warfare agent.
	Soman - An organophosphorus compound that inhibits cholinesterase. It causes seizures and has been used as a chemical warfare agent.
	Tetrachlorvinphos - An organophosphate cholinesterase inhibitor that is used as an insecticide. It has low mammalian toxicity. (From Merck Index, 11th ed)
	Tetraisopropylpyrophosphamide - N,N',N'',N'''-Tetraisopropylpyrophosphamide. A specific inhibitor of pseudocholinesterases. It is commonly used experimentally to determine whether pseudo- or acetylcholinesterases are involved in an enzymatic process.
	Tritolyl Phosphates - A mixture of isomeric tritolyl phosphates. Used in the sterilization of certain surgical instruments and in many industrial processes.

Organophosphorus Compounds Medical Definitions and Terms

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