Canadian Medical Guide > Diseases > Pathological Conditions, Signs and Symptoms > Pathologic Processes > Nerve Degeneration > Retrograde Degeneration Terms and Definitions

Retrograde Degeneration

Medical Definition:	Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.
Also Called:	Retrograde Degeneration, Transneuronal

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