Canadian Medical Guide > Diseases > Neoplasms > Neoplastic Syndromes, Hereditary > Li-Fraumeni Syndrome Terms and Definitions

Li-Fraumeni Syndrome

Medical Definition:	Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. A point mutation of the p53 tumor suppressor gene apparently predisposes family members who inherit it to develop certain cancers.
Guide Notes:	a multiple neopl syndrome; do not use /blood supply /chem /congen /second /secret /ultrastruct
Previously Indexed:	Neoplasms (1982-1986),Neoplastic Syndromes, Hereditary (1987-1991),Syndrome (1982-1986)

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