Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Fusion Proteins, bcr-abl Terms and Definitions

Fusion Proteins, bcr-abl

Medical Definition:	Translation products of a fusion mRNA derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in Abelson murine leukemia virus.
Guide Notes:	IM; found in various leukemias: coord IM with specific leukemia (IM); /drug eff /ultrastruct permitted
Also Called:	Oncogene Protein p190(bcr-abl),Oncogene Protein p210(bcr-abl)
Previously Indexed:	Neoplasm Proteins (1986-1989)

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