Canadian Medical Guide > Chemicals and Drugs > Polycyclic Hydrocarbons > Polycyclic Hydrocarbons, Aromatic > Naphthacenes > Tetracyclines Terms and Definitions

Tetracyclines

Medical Definition:	Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)
Guide Notes:	TETRACYCLINE is also available

Tetracyclines Categories.

	Chlortetracycline - A TETRACYCLINE with a 7-chloro substitution.
	Demeclocycline - A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.
	Doxycycline - A synthetic TETRACYCLINE derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (MALARIA, FALCIPARUM).
	Lymecycline - A semisynthetic antibiotic related to TETRACYCLINE. It is more readily absorbed than TETRACYCLINE and can be used in lower doses.
	Methacycline - A broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.
	Minocycline - A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
	Oxytetracycline - A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
	Rolitetracycline - A pyrrolidinylmethyl TETRACYCLINE.
	Tetracycline - A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.

Tetracyclines Medical Definitions and Terms

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