Canadian Medical Guide > Diseases > Nervous System Diseases > Autoimmune Diseases of the Nervous System > Myasthenia Gravis > Myasthenia Gravis, Neonatal Terms and Definitions

Myasthenia Gravis, Neonatal

Medical Definition:	A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4)
Also Called:	Antenatal Myasthenia Gravis,Myasthenia Gravis, Neonatal, Persistent,Myasthenia Gravis, Neonatal, Transient
Previously Indexed:	Myasthenia Gravis (1965-1999)

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