Canadian Medical Guide > Diseases > Musculoskeletal Diseases > Muscular Diseases > Muscular Disorders, Atrophic > Muscular Dystrophies > Muscular Dystrophy, Duchenne Terms and Definitions

Muscular Dystrophy, Duchenne

Medical Definition:	An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
Also Called:	Becker Muscular Dystrophy
Previously Indexed:	Muscular Dystrophies (1966-1999)

CANADIAN MEDICAL GUIDE

Thank you for visiting Canadian Medical Guide .com