Canadian Medical Guide > Diseases > Musculoskeletal Diseases > Muscular Diseases > Eosinophilia-Myalgia Syndrome Terms and Definitions

Eosinophilia-Myalgia Syndrome

Medical Definition:	A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSPINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
Also Called:	Eosinophilia-Myalgia Syndrome, L-Tryptophan-Related
Previously Indexed:	Eosinophilia/chemically induced (1989-1990),Muscular Diseases/chemically induced (1990),Tryptophan/adverse effects (1989-1990)

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