Canadian Medical Guide > Diseases > Neoplasms > Neoplasms by Site > Endocrine Gland Neoplasms > Multiple Endocrine Neoplasia > Multiple Endocrine Neoplasia Type 2a Terms and Definitions

Multiple Endocrine Neoplasia Type 2a

Medical Definition:	A type of multiple endocrine neoplasia characterized by a virtually 100% incidence of medullary thyroid carcinoma, a 50% incidence of pheochromocytoma, and a lesser incidence of parathyroid adenomas associated with hyperparathyroidism. The condition is always transmitted through autosomal dominant inheritance. Genetic testing can identify individuals with the trait in early infancy. Treatment is usually excision of the enlarged parathyroid glands. (From Holland et al., Cancer Medicine, 3d ed, pp1172-75)
Guide Notes:	IM; coord with specific endocrine/neopl precoords (IM) + specific histol type (IM) if pertinent; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2b is also available; DF: note short X ref
Previously Indexed:	Multiple Endocrine Neoplasia (1966-1994)

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