Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > Multienzyme Complexes > Pyruvate Dehydrogenase Complex Terms and Definitions




Pyruvate Dehydrogenase Complex

Medical Definition: A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE C (LIPOAMIDE), dihydrolipoamide acetyltransferase and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phoshorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Previously Indexed: Oxidoreductases (1966-1972),Pyruvate Oxidase (1966-1972),Pyruvates (1966-1972)
Pyruvate Dehydrogenase Complex Categories.
Canadian Medical Guide Definition Dihydrolipoamide Dehydrogenase - A flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield dihydrolipoamide and NAD+. The enzyme is a component of the multienzyme pyruvate dehydrogenase complex and 2-oxoglutarate dehydrogenase complex. This enzyme was formerly listed as EC 1.6.4.3.
Canadian Medical Guide Definition Pyruvate Dehydrogenase (Lipoamide) - The E1 component of the multienzyme PYRUVATE DEHYDROGENASE COMPLEX. It is composed of 2 alpha subunits (pyruvate dehydrogenase E1 alpha subunit) and 2 beta subunits (pyruvate dehydrogenase E1 beta subunit).

Pyruvate Dehydrogenase Complex Medical Definitions and Terms

CANADIAN MEDICAL GUIDE

Thank you for visiting Canadian Medical Guide .com





Wildlife On Video »

Canadian Medical Guide Canada's Great Outdoors
Tour Canadian Rockies »
Book Banff »
Book Jasper »
Maligne Lake Boat Cruise »
Gondola Banff »
Hike Jasper »
Jasper Columbia Icefield »