Canadian Medical Guide > Chemicals and Drugs > Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Action > Enzyme Inhibitors Terms and Definitions




Enzyme Inhibitors

Medical Definition: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Guide Notes: GEN only; prefer /antag with specific enzyme; DF: ENZYME INHIB
Previously Indexed: Enzymes (1966-1967),Enzymes/antagonists & inhibitors (1968-1974)
Enzyme Inhibitors Categories.
Canadian Medical Guide Definition Carbonic Anhydrase Inhibitors - A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
Canadian Medical Guide Definition Cyclooxygenase Inhibitors - Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
Canadian Medical Guide Definition Folic Acid Antagonists - Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
Canadian Medical Guide Definition Integrase Inhibitors - Compounds which inhibit or antagonize biosynthesis or actions of integrase.
Canadian Medical Guide Definition Lipoxygenase Inhibitors - Compounds or agents that combine with lipoxygenase and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of the eicosanoid products hydroxyeicosatetraenoic acid and various leukotrienes.
Canadian Medical Guide Definition Monoamine Oxidase Inhibitors - A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Canadian Medical Guide Definition Nucleic Acid Synthesis Inhibitors - Compounds that inhibit cell production of DNA or RNA.
Canadian Medical Guide Definition Phosphodiesterase Inhibitors - Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
Canadian Medical Guide Definition Protease Inhibitors - Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
Canadian Medical Guide Definition Protein Synthesis Inhibitors - Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Canadian Medical Guide Definition Uncoupling Agents - Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

Enzyme Inhibitors Medical Definitions and Terms

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