Canadian Medical Guide > Anatomy > Cells > Connective Tissue Cells > Macrophages > Giant Cells, Langhans Terms and Definitions

Giant Cells, Langhans

Medical Definition:	Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.
Guide Notes:	a type of macrophage; do not confuse with LANGERHANS CELLS (cutaneous) nor with ISLETS OF LANGERHANS (pancreatic); A 11 qualif
Previously Indexed:	Granuloma, Giant Cell (1977-1989),Macrophages (1966-1989)

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