Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > Ligases > Carbon-Nitrogen Ligases Terms and Definitions




Carbon-Nitrogen Ligases

Medical Definition: Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.
Guide Notes: DF: C N LIGASES
CAS Number: EC 6.3
Carbon-Nitrogen Ligases Categories.
Canadian Medical Guide Definition Adenylosuccinate Synthase - A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.
Canadian Medical Guide Definition Amide Synthases - Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.
Canadian Medical Guide Definition Argininosuccinate Synthase - An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
Canadian Medical Guide Definition Carbamoyl-Phosphate Synthase (Ammonia) - An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia. This enzyme is specific for arginine biosynthesis or the urea cycle. Absence or lack of this enzyme may cause CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY. EC 6.3.4.16.
Canadian Medical Guide Definition Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor - Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. The linkage is in the form of a carbon-nitrogen bond. EC 6.3.5.
Canadian Medical Guide Definition Formate-Tetrahydrofolate Ligase - A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and TETRAHYDROFOLATE in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Canadian Medical Guide Definition Peptide Synthases - Enzymes that catalyze the joining of an acid and an amino acid by the formation of a carbon-nitrogen bond. EC 6.3.2.

Carbon-Nitrogen Ligases Medical Definitions and Terms

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