Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > Isomerases > Intramolecular Transferases Terms and Definitions

Intramolecular Transferases

Medical Definition:	Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.
CAS Number:	EC 5.4

Intramolecular Transferases Categories.

	2-Acetolactate Mutase - An enzyme involved in the biosynthesis of isoleucine and valine. It converts 2-acetolactate into 3-hydroxy-2-oxo-isovalerate. Also acts on 2-hydroxy-2-acetobutyrate to form 2-hydroxy-2-oxo-3-methylvalerate. EC 5.4.99.3.
	Chorismate Mutase - An isomerase that catalyzes the conversion of chorismic acid to prephenic acid. EC 5.4.99.5.
	Methylmalonyl-CoA Mutase - An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2.
	Phosphotransferases (Phosphomutases) - A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown in some cases that the enzyme has a functional phosphate group, which can act as the donor. These were previously listed under PHOSPHOTRANSFERASES (EC 2.7.-). (From Enzyme Nomenclature, 1992) EC 5.4.2.

Intramolecular Transferases Medical Definitions and Terms

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