Canadian Medical Guide > Chemicals and Drugs > Growth Substances, Pigments, and Vitamins > Growth Substances > Intercellular Signaling Peptides and Proteins > Transforming Growth Factors Terms and Definitions




Transforming Growth Factors

Medical Definition: Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.
Guide Notes: GEN or unspecified; prefer specifics; /drug eff permitted
CAS Type 1 Name: CAS Number: 76057-06-2
Previously Indexed: Growth Substances (1966-1988),Peptides (1966-1988)
Transforming Growth Factors Categories.
Canadian Medical Guide Definition Transforming Growth Factor alpha - Factor isolated in a variety of tissues including epithelium, and maternal decidua. It is closely related to EPIDERMAL GROWTH FACTOR and binds to the EGF receptor. TGF-alpha acts synergistically with TGF-beta in inducing phenotypic transformation, but its physiological role is unknown.
Canadian Medical Guide Definition Transforming Growth Factor beta - A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Transforming Growth Factors Medical Definitions and Terms

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