Canadian Medical Guide > Analytical, Diagnostic and Therapeutic Techniques and Equipment > Therapeutics > Biological Therapy > Immunotherapy > Radioimmunotherapy Terms and Definitions

Radioimmunotherapy

Medical Definition:	Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Guide Notes:	radiother by cytotoxic radioisotopes linked to antibodies: read MeSH definition; do not use /util except by MeSH definition; coord IM with disease /radiother (IM)
Previously Indexed:	Antibodies, Monoclonal/therapeutic use (1984-1991),Immunotherapy (1984-1991),specific radioisotope/therapeutic use (1981-1991)

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