Canadian Medical Guide > Diseases > Immunologic Diseases > Immunologic Deficiency Syndromes > Leukocyte-Adhesion Deficiency Syndrome Terms and Definitions

Leukocyte-Adhesion Deficiency Syndrome

Medical Definition:	Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection.
Guide Notes:	an immunol defic syndrome; DF: LEUKOCYTE ADHESION DEFIC SYNDROME
Previously Indexed:	Immunologic Deficiency Syndromes (1988-1994),Receptors, Leukocyte-Adhesion/deficiency (1988-1990)

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