Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases Terms and Definitions

Peptide Hydrolases

Medical Definition:	A subclass of enzymes from the hydrolase class that catalyze the hydrolysis of peptide bonds. EXOPEPTIDASES and ENDOPEPTIDASES make up the sub-subclasses for this group. EC 3.4.
CAS Number:	EC 3.4

Peptide Hydrolases Categories.

	Endopeptidases - A subclass of PEPTIDE HYDROLASES. They are classified primarily by their catalytic mechanism. Specificity is used only for identification of individual enzymes. They comprise the SERINE ENDOPEPTIDASES, EC 3.4.21; CYSTEINE ENDOPEPTIDASES, EC 3.4.22; ASPARTIC ENDOPEPTIDASES, EC 3.4.23, METALLOENDOPEPTIDASES, EC 3.4.24; and a group of enzymes yet to be assigned to any of the above sub-classes, EC 3.4.99. EC 3.4.-.
	Exopeptidases - A sub-subclass of PEPTIDE HYDROLASES that act only near the ends of polypeptide chains. Exopeptidases are further divided into AMINOPEPTIDASES; EC 3.4.11; DIPEPTIDASES; EC 3.4.13; DIPEPTIDYL PEPTIDASES & tripeptidyl peptidases, EC 3.4.14; peptidyl-dipeptidases, EC 3.4.15; CARBOXYPEPTIDASES; EC 3.4.16 - EC 3.4.18, and omega peptidases, EC 3.4.19. EC 3.4.-.
	Metalloproteases - Proteases which use a metal, normally ZINC, in the catalytic mechanism. This group of enzymes is inactivated by metal CHELATORS.
	Proprotein Convertases - Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.

Peptide Hydrolases Medical Definitions and Terms

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