Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > Hydrolases > Aminohydrolases Terms and Definitions

Aminohydrolases

Medical Definition:
CAS Number:	EC 3.5.4.

Aminohydrolases Categories.

	GTP Cyclohydrolase - (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
	Guanine Deaminase - An enzyme that catalyzes the deamination of guanine to form xanthine. EC 3.5.4.3.
	Methenyltetrahydrofolate Cyclohydrolase - An aminohydrolase that catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. In most higher eucaryotic organisms this enzyme also includes METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP) and FORMATE-TETRAHYDROFOLATE LIGASE activities.
	Nucleoside Deaminases - Catalyze the hydrolysis of nucleosides with the elimination of ammonia.
	Nucleotide Deaminases - Catalyze the hydrolysis of nucleotides with the elimination of ammonia.

Aminohydrolases Medical Definitions and Terms

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