Canadian Medical Guide > Chemicals and Drugs > Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Gastrointestinal Hormones Terms and Definitions
Gastrointestinal Hormones
Medical Definition: | HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs. |
Also Called: | Enteric Hormones |
Cholecystokinin - A 33-amino acid peptide secreted by the upper intestinal mucosa and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety. | |
Enteroglucagon - Glucagon-like polypeptide secreted in the intestinal tract. It does not share a common receptor site with pancreatic glucagon. The peptide has glycogenolytic activity. | |
Epidermal Growth Factor - A 6 kD polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. EPIDERMAL GROWTH FACTOR exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and epithelial cells. | |
Gastric Inhibitory Polypeptide - A gastrointestinal hormone consisting of a 43-amino acid polypeptide (molecular weight 5105). It inhibits gastric secretion and motility and stimulates release of insulin. | |
Gastrin-Releasing Peptide - Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the stomach, the neuropeptide stimulates release of gastrin from the G CELLS. | |
Gastrins - A family of gastrointestinal peptide hormones that excite the secretion of gastric juices. They may also occur in the central nervous system where they are presumed to be neurotransmitters. | |
Motilin - A 22-amino acid polypeptide (molecular weight 2700) isolated from the duodenum. At low pH it inhibits gastric motor activity, whereas at high pH it has a stimulating effect. | |
Peptide YY - A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion. | |
Secretin - A hormone of the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597) | |
Vasoactive Intestinal Peptide - A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE). |
Gastrointestinal Hormones Medical Definitions and Terms
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