Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 3-Ring > Phenothiazines Terms and Definitions

Phenothiazines

Medical Definition:

Compounds containg dibenzo-1,4-thiazine. Some of them are neuroactive.

Phenothiazines Categories.

	Acepromazine - A phenothiazine that is used in the treatment of PSYCHOSES.
	Azure Stains - PHENOTHIAZINES with an amino group at the 3-position that are green crystals or powder. They are used as biological stains.
	Chlorpromazine - The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
	Fluphenazine - A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.
	Mesoridazine - A phenothiazine antipsychotic with effects similar to CHLORPROMAZINE.
	Methotrimeprazine - A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
	Methylene Blue - A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
	Nonachlazine - Coronary vasodilator with a novel mechanism of action; proposed as antianginal agent.
	Perazine - A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects.
	Perphenazine - An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
	Prochlorperazine - A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
	Promazine - A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
	Thioridazine - A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than CHLORPROMAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618)
	Tolonium Chloride - A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.
	Trifluoperazine - A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
	Triflupromazine - A phenothiazine used as an antipsychotic agent and as an antiemetic.
	Trimeprazine - A phenothiazine derivative that is used as an antipruritic.

Phenothiazines Medical Definitions and Terms

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