Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Benzimidazoles Terms and Definitions

Benzimidazoles

Medical Definition:

Benzimidazoles Categories.

	Albendazole - A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
	Astemizole - A long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria. The drug is well tolerated and has no anticholinergic side effects.
	Bisbenzimide - A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
	Cambendazole - A nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.
	Mebendazole - A nematocide in humans and animals. It acts by interfering with the carbohydrate metabolism and associated energy production of the parasite.
	Mibefradil - A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
	Nocodazole - Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.
	Omeprazole - A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.
	Pimozide - A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

Benzimidazoles Medical Definitions and Terms

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