Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrrolidines Terms and Definitions

Pyrrolidines

Medical Definition:
Guide Notes:	do not confuse with PYRROLIDONES or PYRROLIDINONES

Pyrrolidines Categories.

	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (CORTICOTROPIN) via the release of hypothalmic arginine vasopressin (ARGIPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)
	Anisomycin - An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
	Bepridil - A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
	Clemastine - A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
	Kainic Acid - (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
	Lincomycin - An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
	Nafoxidine - An estrogen antagonist that has been used in the treatment of breast cancer.
	Nitromifene - A non-steroidal estrogen antagonist (as the 1:1 citrate) most commonly used as a research tool in animal studies.
	Pentolinium Tartrate - A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
	Procyclidine - A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
	Pyrrolidinones - A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck Index, 11th ed)
	Tremorine

Pyrrolidines Medical Definitions and Terms

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