Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Oxazoles Terms and Definitions

Oxazoles

Medical Definition:	Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position.
Guide Notes:	includes oxazolines, oxazolidines
Also Called:	Munchnones

Oxazoles Categories.

	Aminorex - An amphetamine-like anorectic agent. It may cause pulmonary hypertension.
	Dimethadione - An anticonvulsant that is the active metabolite of TRIMETHADIONE.
	Fura-2 - A fluorescent calcium chelating agent which is used to study intracellular calcium in many tissues. The fluorescent and chelating properties of Fura-2 aid in the quantitation of endothelial cell injury, in monitoring ATP-dependent calcium uptake by membrane vesicles, and in the determination of the relationship between cytoplasmic free calcium and oxidase activation in rat neutrophils.
	Ibotenic Acid - A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
	Isoxazoles
	Muscimol - Neurotoxic isoxazole isolated from Amanita muscaria and A. phalloides and also obtained by decarboxylation of IBOTENIC ACID. It is a potent agonist at GABA-A receptors and is used mainly as an experimental tool in animal and tissue studies.
	Oxadiazoles
	Oxazolidinones - Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.
	Oxazolone - Immunologic adjuvant and sensitizing agent.
	Pemoline - A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
	Trimethadione - An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)

Oxazoles Medical Definitions and Terms

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