Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Imidazoles Terms and Definitions

Imidazoles

Medical Definition:
Guide Notes:	includes imidazolines, imidazolidines

Imidazoles Categories.

	Aminoimidazole Carboxamide - An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.
	Antazoline - An antagonist of histamine H1 receptors.
	Biotin - A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
	Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide - An inhibitor of the last step of noradrenaline biosynthesis.
	Carbimazole - An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.
	Clonidine - An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)
	Clotrimazole - An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
	Creatinine
	Dexmedetomidine - A selective inhibitor of RECEPTORS, ADRENERGIC ALPHA-2 that has analgesic and sedative properties. MEDETOMIDINE is the other racemic form.
	Econazole - A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.
	Enoximone - 1,3-Dihydro-4-methyl-5-(4-(methylthio)benzoyl)-2H-imidazol-2-one. A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with congestive heart failure.
	Ethylenethiourea - A degradation product of ethylenebis(dithiocarbamate) fungicides. It has been found to be carcinogenic and to cause thyroid hyperplasia.
	Etimizol - A xanthine-related, putative nootropic drug.
	Etomidate - Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
	Fluspirilene - A long-acting injectable antipsychotic agent used for chronic schizophrenia.
	Hydantoins
	Levamisole - An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
	Medetomidine - An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.
	Miconazole - An imidazole antifungal agent that is used topically and by intravenous infusion.
	Naphazoline - An adrenergic vasoconstrictor agent used as a decongestant.
	Niridazole - An antischistosomal agent that has become obsolete.
	Ondansetron - A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
	Oxymetazoline - A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
	Phentolamine - A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
	Ro 20-1724 - Inhibitor of phosphodiesterases.
	Tetramisole
	Tolazoline - A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
	Trimethaphan - A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.

Imidazoles Medical Definitions and Terms

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Imidazoles

Imidazoles Medical Definitions and Terms

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