Canadian Medical Guide > Diseases > Nervous System Diseases > Nervous System Malformations > Hereditary Motor and Sensory Neuropathies > Spastic Paraplegia, Hereditary Terms and Definitions

Spastic Paraplegia, Hereditary

Medical Definition:	A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progessive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Guide Notes:	coord with GENES, DOMINANT or GENES, RECESSIVE if discussed
Also Called:	Autosomal Recessive Hereditary Spastic Paraplegia,Hereditary Autosomal Dominant Spastic Paraplegia,Hereditary X-linked Recessive Spastic Paraplegia,X-linked, Spastic Paraplegia, Hereditary
Previously Indexed:	Muscle Spasticity/genetics (1975-1988),Paraplegia/genetics (1966-1988)

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