Canadian Medical Guide > Biological Sciences > Genetic Structures > Genes > Genes, T-Cell Receptor Terms and Definitions




Genes, T-Cell Receptor

Medical Definition: DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. The TcR genes are formed by somatic rearrangement (see GENE REARRANGEMENT, T-LYMPHOCYTE and its children) of germline gene segments, and resemble Ig genes in their mechanisms of diversity generation and expression.
Guide Notes: GEN or unspecified; prefer specifics; DF: note short X ref
Genes, T-Cell Receptor Categories.
Canadian Medical Guide Definition Genes, T-Cell Receptor alpha - DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes.
Canadian Medical Guide Definition Genes, T-Cell Receptor beta - DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.
Canadian Medical Guide Definition Genes, T-Cell Receptor delta - DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus.
Canadian Medical Guide Definition Genes, T-Cell Receptor gamma - DNA sequences encoding the gamma chain of the T-cell receptor. The human gamma-chain locus is organized similarly to the TcR beta-chain locus.

Genes, T-Cell Receptor Medical Definitions and Terms

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