Canadian Medical Guide > Biological Sciences > Genetic Structures > Genes > Genes, T-Cell Receptor Terms and Definitions

Genes, T-Cell Receptor

Medical Definition:	DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. The TcR genes are formed by somatic rearrangement (see GENE REARRANGEMENT, T-LYMPHOCYTE and its children) of germline gene segments, and resemble Ig genes in their mechanisms of diversity generation and expression.
Guide Notes:	GEN or unspecified; prefer specifics; DF: note short X ref

Genes, T-Cell Receptor Categories.

	Genes, T-Cell Receptor alpha - DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes.
	Genes, T-Cell Receptor beta - DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.
	Genes, T-Cell Receptor delta - DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus.
	Genes, T-Cell Receptor gamma - DNA sequences encoding the gamma chain of the T-cell receptor. The human gamma-chain locus is organized similarly to the TcR beta-chain locus.

Genes, T-Cell Receptor Medical Definitions and Terms

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