Canadian Medical Guide > Biological Sciences > Genetic Structures > Genes > Genes, MDR Terms and Definitions




Genes, MDR

Medical Definition: Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian P-glycoproteins are encoded by small MDR gene familes. The human multidrug resistance 1 (MDR1) gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (Biochem Biophys Res Commun 1994;199(3):1428-35; Cancer Res 1994:54(6):1536-41)
Also Called: Multidrug Resistance Gene-1
Previously Indexed: Drug Resistance (1986-1994),Drug Resistance, Multiple (1995-1996),Multigene Family (1989-1996)

Genes, MDR Medical Definitions and Terms

CANADIAN MEDICAL GUIDE

Thank you for visiting Canadian Medical Guide .com





Wildlife On Video »

Canadian Medical Guide Canada's Great Outdoors
Tour Canadian Rockies »
Book Banff »
Book Jasper »
Maligne Lake Boat Cruise »
Banff Gondola »
Hike Jasper »
Jasper Columbia Icefield »
Hike Johnston Canyon »
Golden Skybridge »
Lake Minnewanka Boat Cruise »
Columbia Icefields Skywalk »