Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Alkaloids > Ergot Alkaloids > Ergotamines Terms and Definitions

Ergotamines

Medical Definition:	A series of structurally-related alkaloids containing the ergotaman backbone structure.
Previously Indexed:	Ergolines (1969-1974),Ergotamine (1966-1974)

Ergotamines Categories.

	Bromocriptine - A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.
	Dihydroergocornine - A 9,10alpha-dihydro derivative of ERGOTAMINE that contains isopropyl sidechains at the 2' and 5' positions of the molecule.
	Dihydroergocristine - A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position of the molecule.
	Dihydroergocryptine - A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position and an alpha-isobutyl sidechain at 5'alpha position of the molecule.
	Dihydroergotamine - A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of migraine.
	Dihydroergotoxine - A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE, DIHYDROERGOCRISTINE, and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.
	Ergotamine - A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of MIGRAINE.

Ergotamines Medical Definitions and Terms

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