Canadian Medical Guide > Diseases > Endocrine Diseases > Polyendocrinopathies, Autoimmune Terms and Definitions

Polyendocrinopathies, Autoimmune

Medical Definition:	Autoimmune disease affecting multiple endocrine organs. Type I is characterized by childhood onset and mucocutaneous candidiasis, while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis, hypoparathyroidism, and gonadal failure. In both types organ-specific antibodies against a variety of endocrine glands have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
Guide Notes:	a multiple endocrine disord so do not coord with specific endocrine dis or precoord endocr dis term unless particularly discussed; do not index under CANDIDIASIS unless particularly discussed: see MeSH definition; DF: APECED
Also Called:	Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy,Polyglandular Type I Autoimmune Syndrome,Autoimmune Syndrome Type II, Polyglandular
Previously Indexed:	Autoimmune Diseases (1968-1991),Endocrine Diseases (1978-1991)

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