Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > DNA Repair Enzymes > DNA-(Apurinic or Apyrimidinic Site) Lyase Terms and Definitions

DNA-(Apurinic or Apyrimidinic Site) Lyase

Medical Definition:	A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
CAS Number:	EC 4.2.99.18
Previously Indexed:	Carbon-Oxygen Lyases (1978-2003)

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