Canadian Medical Guide > Chemicals and Drugs > Enzymes and Coenzymes > Enzymes > DNA Repair Enzymes > DNA Glycosylases Terms and Definitions




DNA Glycosylases

Medical Definition: A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.
Also Called: Methylpurine DNA Glycosylase
CAS Number: EC 3.2.2.-
Previously Indexed: DNA (1978-1981),Glycoside Hydrolases (1978-1981),N-Glycosyl Hydrolases (1982-2003)
DNA Glycosylases Categories.
Canadian Medical Guide Definition DNA-Formamidopyrimidine Glycosylase - A DNA repair enzyme that is an N-glycosyl hydrolase with specificity for DNA-containing ring-opened N(7)-methylguanine residues.
Canadian Medical Guide Definition Thymine DNA Glycosylase - An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N-glycosidic bond. These mispaired nucleotides generally occur through the hydrolytic DEAMINATION of 5-METHYLCYTOSINE to thymine.

DNA Glycosylases Medical Definitions and Terms

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