Canadian Medical Guide > Diseases > Nervous System Diseases > Autoimmune Diseases of the Nervous System > Disease Models, Autoimmune, Nervous System > Neuritis, Experimental Allergic Terms and Definitions

Neuritis, Experimental Allergic

Medical Definition:	An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Guide Notes:	DF: NEURITIS EXPER ALLERGIC
Previously Indexed:	Myelin Sheath (1966-1981),Neuritis (1966-1981),Peripheral Nerves (1966-1981)

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