Canadian Medical Guide > Diseases > Nervous System Diseases > Autoimmune Diseases of the Nervous System > Disease Models, Autoimmune, Nervous System > Myasthenia Gravis, Experimental Autoimmune Terms and Definitions

Myasthenia Gravis, Experimental Autoimmune

Medical Definition:	Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Also Called:	Passive Transfer Experimental Autoimmune Myasthenia Gravis
Previously Indexed:	Autoimmune Diseases (1969-1999),Myasthenia Gravis (1968-1999)

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