Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 3-Ring > Dibenzazepines > Clozapine Terms and Definitions

Clozapine

Medical Definition:	A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Also Called:	Clozaril,Leponex
CAS Type 1 Name:	CAS Number:	5786-21-0
Previously Indexed:	Dibenzazepines (1971-1974),Piperazines (1971-1974)

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