Canadian Medical Guide > Biological Sciences > Biological Phenomena, Cell Phenomena, and Immunity > Immunity > Cytotoxicity, Immunologic > Antibody-Dependent Cell Cytotoxicity Terms and Definitions

Antibody-Dependent Cell Cytotoxicity

Medical Definition:	The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Guide Notes:	DF: note short X ref
Previously Indexed:	Cytotoxicity Tests, Immunologic (1971-1977),Immunity, Cellular (1970-1977),Lymphocytes (1966-1977)

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