Canadian Medical Guide > Chemicals and Drugs > Immunologic and Biological Factors > Immunologic Factors > Cytokines > Lymphokines Terms and Definitions

Lymphokines

Medical Definition:	Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
Guide Notes:	/biosyn /drug eff /physiol /ultrastruct permitted

Lymphokines Categories.

	Leukocyte Migration-Inhibitory Factors - Protein factor(s) released by sensitized lymphocytes (and possibly other cells) that inhibit the movement of leukocytes, especially polymorphonuclear cells, away from their site of release. Assays for these factors are used as tests for cellular immunity. Two of the common assays are the leukocyte migration capillary tube technique (LMCT) and the leukocyte migration agarose technique (LMAT).
	Macrophage Migration-Inhibitory Factors - Proteins released by sensitized lymphocytes and possibly other cells that inhibit the migration of macrophages away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.
	Macrophage-Activating Factors - Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is interferon-gamma (INTERFERON TYPE II). Other factors antigenically distinct from IFN-gamma have also been identified.
	Suppressor Factors, Immunologic - Proteins, protein complexes, or glycoproteins secreted by suppressor T-cells that inhibit either subsequent T-cells, B-cells, or other immunologic phenomena. Some of these factors have both histocompatibility (I-J) and antigen-specific domains which may be linked by disulfide bridges. They can be elicited by haptens or other antigens and may be mass-produced by hybridomas or monoclones in the laboratory.
	Transfer Factor - Factor derived from leukocyte lysates of immune donors which can transfer both local and systemic cellular immunity to nonimmune recipients.

Lymphokines Medical Definitions and Terms

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