Canadian Medical Guide > Analytical, Diagnostic and Therapeutic Techniques and Equipment > Investigative Techniques > Genetic Techniques > Chromosome Mapping > Physical Chromosome Mapping Terms and Definitions

Physical Chromosome Mapping

Medical Definition:	Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)
Previously Indexed:	Chromosome Mapping (1968-1998)

Physical Chromosome Mapping Categories.

	Contig Mapping - Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.
	Radiation Hybrid Mapping - A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
	Restriction Mapping - Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.

Physical Chromosome Mapping Medical Definitions and Terms

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