Canadian Medical Guide > Diseases > Pathological Conditions, Signs and Symptoms > Pathologic Processes > Chromosome Aberrations > Nondisjunction, Genetic Terms and Definitions




Nondisjunction, Genetic

Medical Definition: The failure of homologous CHROMOSOMES or CHROMATIDS to segregate during MITOSIS or MEIOSIS with the result that one daughter cell has both of a pair of parental chromosomes or chromatids and the other has none.
Previously Indexed: Cell Division (1966-1967),Chromosome Aberrations (1968-1981),Chromosomes (1966-1967),Meiosis (1968-1981)
Nondisjunction, Genetic Categories.
Canadian Medical Guide Definition Uniparental Disomy - The presence in a cell of two paired chromosomes from the same parent, with no chromosome of that pair from the other parent. This chromosome composition stems from non-disjunction (NONDISJUNCTION, GENETIC) events during MEIOSIS. The disomy may be composed of both homologous chromosomes from one parent (heterodisomy) or a duplicate of one chromosome (isodisomy).

Nondisjunction, Genetic Medical Definitions and Terms

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