Canadian Medical Guide > Anatomy > Cells > Cells, Cultured > Cell Line > Cell Line, Transformed Terms and Definitions




Cell Line, Transformed

Medical Definition: Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
Guide Notes: almost always NIM with no subheadings; check ANIMALS or HUMAN; do not routinely add tissue or organ
Previously Indexed: Cell Line (1966-1987),Cell Transformation, Neoplastic (1966-1987),Cell Transformation, Viral (1978-1987),Cells, Cultured (1966-1987),Tissue Culture (1966-1976)
Cell Line, Transformed Categories.
Canadian Medical Guide Definition COS Cells - CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)

Cell Line, Transformed Medical Definitions and Terms

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