Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > p14ARF Protein Terms and Definitions




p14ARF Protein

Medical Definition: A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of mdm2 protein (which regulates p53 by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is PROTEIN P16. Both p16 gene products have tumor suppressor functions.
Previously Indexed: Proteins (1995-2001)

p14ARF Protein Medical Definitions and Terms

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