Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Fibrin Terms and Definitions

Fibrin

Medical Definition:	A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
Also Called:	Antithrombin I
CAS Type 1 Name:	CAS Number:	9001-31-4

Fibrin Categories.

	Fibrin Fibrinogen Degradation Products - Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.
	Fibrin Foam - A dry artificial sterile sponge of fibrin prepared by clotting with thrombin a foam or solution of fibrinogen. It is used in conjunction with thrombin as a hemostatic in surgery at sites where bleeding cannot be controlled by more common methods. (From Martindale, The Extra Pharmacopoeia, 30th ed, p648)
	Fibrin Tissue Adhesive - An autologous or commercial tissue adhesive containing fibrinogen and thrombin. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, Factor VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as aprotinin. Mixing of the two components promotes clotting and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, hemostasis, and wound healing.

Fibrin Medical Definitions and Terms

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