Canadian Medical Guide > Diseases > Hemic and Lymphatic Diseases > Hematologic Diseases > Blood Protein Disorders > Paraproteinemias Terms and Definitions




Paraproteinemias

Medical Definition: A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.
Also Called: Gammopathy, Monoclonal,Plasma Cell Dyscrasias
Previously Indexed: Blood Protein Disorders (1966-1975),Immunoglobulins (1970-1975),specific immunoglobulin (1971-1975)
Paraproteinemias Categories.
Canadian Medical Guide Definition Heavy Chain Disease - A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.

Paraproteinemias Medical Definitions and Terms

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