Canadian Medical Guide > Chemicals and Drugs > Immunologic and Biological Factors > Biological Factors > Blood Coagulation Factor Inhibitors > Lupus Coagulation Inhibitor Terms and Definitions

Lupus Coagulation Inhibitor

Medical Definition:	An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC), ANTIPHOSPHOLIPID SYNDROME, and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
Guide Notes:	DF: LUPUS COAG INHIB
Previously Indexed:	Autoantibodies (1966-1991),Blood Coagulation Factors (1966-1991)

CANADIAN MEDICAL GUIDE

Thank you for visiting Canadian Medical Guide .com