Canadian Medical Guide > Analytical, Diagnostic and Therapeutic Techniques and Equipment > Therapeutics > Biological Therapy > Gene Therapy Terms and Definitions

Gene Therapy

Medical Definition:	The introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Techniques include insertion of retroviral vectors, transfection, homologous recombination, and injection of new genes into the nuclei of single cell embryos. The entire gene therapy process may consist of multiple steps. The new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia.
Also Called:	Gene Therapy, Somatic
Previously Indexed:	Genetic Intervention (1973-1988)

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