Canadian Medical Guide > Chemicals and Drugs > Immunologic and Biological Factors > Biological Factors > Biological Markers > Antigens, Differentiation Terms and Definitions

Antigens, Differentiation

Medical Definition:	Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
Guide Notes:	GEN: prefer specific groups & specific differentiation antigens; note X ref LEU ANTIGENS but several specific Leu antigens are also available; DF: ANTIGENS DIFFER
Also Called:	Differentiation Antigens, Hairy Cell Leukemia,Leu Antigens
Previously Indexed:	Antigens (1966-1977),Antigens, Neoplasm (1973-1987),Antigens, Surface (1979-1987),Cell Differentiation (1966-1987),Cell Transformation, Neoplastic (1970-1987),specific cell or tissue (1966-1987)

Antigens, Differentiation Categories.

	Antigens, CD - Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similiar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
	Antigens, Differentiation, B-Lymphocyte - Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.
	Antigens, Differentiation, Myelomonocytic - Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
	Antigens, Differentiation, T-Lymphocyte - Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.
	Antigens, Ly - A group of lymphocyte surface antigens differentially located on subpopulations of mouse lymphocytes. This localization has been useful in distinguishing different functional subpopulations of lymphocytes. For example, cytotoxic T-cells bear primarily Lyt-23 on their surface and not Lyt-1, whereas helper cells bear Lyt-1 and not Lyt-23.

Antigens, Differentiation Medical Definitions and Terms

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