Canadian Medical Guide > Chemicals and Drugs > Immunologic and Biological Factors > Biological Factors > Biological Markers > Antibodies, Antineutrophil Cytoplasmic Terms and Definitions

Antibodies, Antineutrophil Cytoplasmic

Medical Definition:	Autoantibodies directed against cytoplasmic constituents of polymorphonuclear leukocytes and/or monocytes. They are used as specific markers for Wegener's granulomatosis and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.
Guide Notes:	autoantibodies; do not coord with ANTIBODY FORMATION for /biosyn; DF: note short X ref
Also Called:	c-ANCA,p-ANCA
Previously Indexed:	Autoantibodies (1991-1996)

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