Canadian Medical Guide > Biological Sciences > Biochemical Phenomena, Metabolism, and Nutrition > Biochemical Phenomena > Binding Sites Terms and Definitions

Binding Sites

Medical Definition:	The reactive parts of a macromolecule that directly participate in its specific combination with another molecule.
Guide Notes:	NIM; note category; restrict to site of binding: do not use as substitute for chem or metab mechanism of binding; do not coord with RECEPTORS terms unless the site of binding is particularly discussed
Also Called:	Active Site
Previously Indexed:	Antigen-Antibody Reactions (1966-1967),Enzymes (1966-1967)

Binding Sites Categories.

	Allosteric Site - A site on an enzyme which upon binding of a modulator, causes the protein to undergo a conformational change that may alter the catalytic or binding properties of the enzyme.
	Bay Region (Chemistry) - An indentation of three fused benzene rings. A common bay region is the site on BENZO(A)PYRENE, an indirect carcinogen that is metabolically activated by the P-450 system at the 7,8-double bond, leading to a 7,8-oxide, which is rapidly converted to a 7,8-dihydrodiol and later epoxidated near the bay region at the 9,10-double bond. The resulting product, a diol-epoxide is a poor substrate for epoxide hydratase and is released from the mitochondria into the cell as a highly reactive electrophil, becoming an 'ultimate' carcinogen, as it reacts with negative charges in DNA. (From Segen, Dictionary of Modern Medicine, 1992)
	Binding, Competitive

Binding Sites Medical Definitions and Terms

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