Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Bacterial Proteins > Zinostatin Terms and Definitions

Zinostatin

Medical Definition:	An antitumor isolate from the culture filtrate of the F-41 variant of Streptomyces carzinostaticus. It is a protein of known amino acid sequence with a molecular weight of approximately 11,500 and possessing a regulatory function on the metabolism of DNA. In this process, that is first an inhibition of DNA biosynthesis followed by the degradation of DNA, zinostatin functions in a manner analogous to that of the much higher molecular weight antibiotic MITOMYCIN. Zinostatin is also a potent cytostatic agent active against gram-positive organisms.
Guide Notes:	an antineoplastic antibiotic
CAS Type 1 Name:	CAS Number:	9014-02-2
Previously Indexed:	Antibiotics, Antineoplastic (1971-1974),Bacterial Proteins (1974)

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